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英夫利昔单抗内标（Infliximab Stable-Isotope Labeled Monoclonal Antibody ）

更新时间：2025-06-27

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简要描述：

英夫利昔单抗内标（Infliximab Stable-Isotope Labeled Monoclonal Antibody ）产品编号：CMS-MSQC9-100UG产品规格：100ug储存条件：-20度价格：询价

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产品介绍：

性质

Related Categories	Antibody Characterization and Analysis, SILuMAb and SigmaMAb Antibody Standards for Mass Spec Analysis, 分子生物学, 生化试剂, 用于质谱分析的多肽及蛋白标准品, 蛋白质及衍生物, 蛋白质组学, 质谱更多...
recombinant	expressed in CHO cells
antibody product type	primary antibodies
assay	≥90% (SDS-PAGE)
packaging	vial of 100 μg
shipped in	wet ice
storage temp.	−20°C

Preparation Note

Produced utilizing enriched media containing stable isotope labeled amino acids are ¹³C₆, ¹⁵N₄-labeled Arginine and ¹³C₆, ¹⁵N₂-labeled Lysine.

Infliximab Stable-Isotope Labeled Monoclonal Antibody is designed to be used as a internal standard for analysis of Infliximab in human serum.

Reconstitution

Infliximab recovery is maximized when 0.1% formic acid is used for reconstitution of the lyophilized product.Reconstitution with other solvents may reduce recovery. Do not freeze after reconstitution.

• Briefly centrifuge the vial at ~10,000 × g to collect the product at the bottom of the vial.
• Add 500 μL of ultrapure water containing 0.1% formic acid to the vial.
• Mix the contents by gently inverting the vial a minimum of 5 times.
• Allow the vial to stａnd at room temperature for at least 15 minutes and repeat mixing by inversion.

Physical form

Each vial of Infliximab Stable-Isotope Labeled Monoclonal Antibody contains the labeled antibody in a lyophilized form containing phosphate buffered saline.

Application

Poster: Quantification of Infliximab in Human Serum by LC-MS/MS Using A Full-Length Stable Isotope Labeled Internal Standard

General description

Infliximab Stable-Isotope Labeled Monoclonal Antibody (MSQC9) is a recombinant, stable isotope-labeled, monoclonal antibody which incorporates [¹³C₆, ¹⁵N₄]-Arginine and [¹³C₆, ¹⁵N₂]-Lysine. Expressed in CHO cells, it is designed to be used as an internal standard for the quantitative mass spectrometry analysis of Infliximab in human serum. Infliximab is a chimeric monoclonal antibody biologic drug that works against tumor necrosis factor alpha (TNF-a) and is used to treat autoimmune diseases.
Infliximab has been approved for the treatment of Crohn′s disease, ulcerative colitis, psoriasis, psoriatic arthritis, ankylosing spondylitis, and rheumatoid arthritis.Infliximab Stable-Isotope Labeled Monoclonal Antibody is for research use only and is not intended for diagnostic or therapeutic use.

Peptide	z (Q1)	Q1 m/z	Q3 m/z	Fragment ion type	Dwell (ms)	DP	CE
DILLTQSPAILSVSPGER	2	948.525	1125.626	y11	50	100.3	43.0
DILLTQSPAILSVSPGER	2	948.525	731.368	y7	50	100.3	43.0
DILLTQSPAILSVSPGER	2	948.525	458.236	y4	50	100.3	43.0
DILLTQSPAILSVSPGE[R]	2	953.530	1135.635	y11	50	100.3	43.0
DILLTQSPAILSVSPGE[R]	2	953.530	741.377	y7	50	100.3	43.0
DILLTQSPAILSVSPGE[R]	2	953.530	468.244	y4	50	100.3	43.0
YASESMSGIPSR	2	642.798	1050.488	y10	50	78.0	32.0
YASESMSGIPSR	2	642.798	747.382	y7	50	78.0	32.0
YASESMSGIPSR	2	642.798	616.341	y6	50	78.0	32.0
YASESMSGIPS[R]	2	647.802	1060.497	y10	50	78.0	32.0
YASESMSGIPS[R]	2	647.802	757.390	y7	50	78.0	32.0
YASESMSGIPS[R]	2	647.802	626.350	y6	50	78.0	32.0
GLEWVAEIR	2	536.793	773.430	y6	50	70.2	28.2
GLEWVAEIR	2	536.793	587.351	y5	50	70.2	28.2
GLEWVAEIR	2	536.793	488.283	y4	50	70.2	28.2
GLEWVAEI[R]	2	541.797	783.439	y6	50	70.2	28.2
GLEWVAEI[R]	2	541.797	597.359	y5	50	70.2	28.2
GLEWVAEI[R]	2	541.797	498.291	y4	50	70.2	28.2
SINSATHYAESVK	2	703.849	1092.532	y10	50	82.4	34.2
SINSATHYAESVK	2	703.849	833.415	y7	50	82.4	34.2
SINSATHYAESVK	3	469.569	603.791	y11+2	50	65.3	23.1
SINSATHYAESV[K]	2	707.856	1100.546	y10	50	82.4	34.2
SINSATHYAESV[K]	2	707.856	841.429	y7	50	82.4	34.2
SINSATHYAESV[K]	3	472.240	607.798	y11+2	50	65.3	23.1